24Genetics Health and Wellness DNA test: the key to prevention
If you care about your health and want prevent diseases The health DNA test is what you need. Thanks to the information that your DNA offers us, you can plan your revisions better, identify where you have to be more attentive, what risks are there and what solutions you must take to face them. Genetic data about your metabolism will help your doctors better understand your body, and the pharmacogenetics part will help them choose the most appropriate drugs for you.
Acting on time can be the big difference. Early Diagnosis multiply between 5 and 10 the chances of success in many diseases such as cancer. With the information of this genetic test your doctors will be able to establish the protocols of review of the diseases to which you have greater genetic predisposition, to be able to detect them in time in the case in which they are developed.
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La Personalized medicine is the future, and thanks to 24Genetics is the present for everyone who wants it. It is a fact that each person's medicines take effect in a different way. The secret is hidden in our genetics. With the Pharmacogenetics section of this DNA test your doctors will know which medicines are the most suitable for you, how to adjust the doses and which ones to avoid. It's precision medicine.
Genetics can also help us to avoid Genetic Diseases in our Descent. There are many rare diseases that you can know beforehand if you have a risk of your children suffering, even if neither you nor your partner have ever suffered. If you have a background in your family, the first thing you have to do is go to your specialist doctor to assess the type of test you must do. In the genetic test of health and well-being we can see many of them, and if detected, there are techniques to reduce the risk of transmitting them to our children and grandchildren.
This DNA test analyzes More than 200 diseases, the genetic predisposition of dozens of biomarkers, more than 20 medications, and a set of genetic data of maximum utility for your doctors.
In this test we read more than 700.000 genetic markers where we can analyze the largest amount of useful health information available to date. We apply your genetic information to prestigious international studies through which we reach the conclusions you can read in your report.
Thanks to our pre-study of Ancestors, we apply the algorithms according to your ancestral roots, since the genetic predisposition algorithms of a European, an Asian or an African, in many cases, are radically different. We are the only company in Europe with this technology.
This test includes, free of charge, a consultation of the Telephone Genetic Counsel. Follow the instructions that we will send you by email to be able to reserve day and time. From 24Genetics we recommend all our clients to accompany their genetic health test with a Genetic Counseling consultation.
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These are the Sections and sections of our health DNA test:
Complex Diseases: GWAS
For this section of our report we apply GWAS publications, a type of study that compares the DNA markers of people with a disease, with people without this disease, in order to identify genetic differences. These studies can be very useful for prevention and early diagnosis, because not being a diagnostic tool it tells us what we should be more attentive to.
The data that the application of these studies will provide to your genetic information is your predisposition towards the rest of the population. At no time does it mean that you are going to suffer the disease, it only indicates that statistically and according to this study you might have something more predisposed than most of the population; we indicate that you have more predisposition when it is greater than ninety percent of the population, and lower if your predisposition is lower than that of ninety percent of the population. It is normal that a few pathologies result with a greater predisposition.
It is important to bear in mind that in complex diseases many factors influence, the genetic ones are only a part; the lifestyle, the feeding, etc are in many cases those that can be more influential.
Complex diseases: mutations
In this section we analyze the mutations of the most important genes from the oncological point of view. We look for mutations suspected of being pathogenic, specifically those reported as pathogenic in the ClinVar database.
It is important to note that this test does not sequence the entire genome, we only analyze 700.000 of the 3.200 millions of genetic links so, in the case that we do not find any mutation, that does not mean that we are not carriers, since it can be in zones genetic that we are not analyzing. Specifically in this section we analyze a small percentage of the genes classified as pathogens in the databases consulted, so there may be mutations in some region not studied that we will not be able to see.
Hereditary diseases are susceptible to being transmitted to your descendants. Most of them can be a carrier and have never suffered, but there is a risk that our offspring will suffer. They are mostly monogenetic diseases.
In this group we look for pathogenic mutations, or that it is suspected that they could be, in the genes involved in these diseases. The mutations that we are looking for are those that are reported in some of the most important global genetic databases, basically OMIM and ClinVar.
As in the previous section, we did not analyze all the genetic information related to each disease, specifically in this section we were able to analyze on average something less than half of the pathogenic markers reported in the databases consulted, so we could have mutations in the other half and not see them in this report.
It is important to bear in mind that if you need a diagnosis about a specific disease, there are genetic tests that analyze the entire gene or genes involved in said disease valid for clinical use. If you have a family history, we recommend that you consult your doctor or geneticist to study the need to perform a test of this type.
Biomarkers, biometrics and traits:
In this section we use, again, the GWAS statistical analyzes to calculate your genetic predisposition to have abnormal levels of certain metabolic parameters.
As in the rest of our GWAS studies, we indicate that you have more predisposition when it is greater than ninety percent of the population, and lower if your predisposition is lower than that of ninety percent of the population. Due to the statistical distribution of this analysis, it is normal that several parameters with more or less predisposition come out.
In this section we study your genetic predisposition towards certain medications. Depending on the drug, your genetics can affect the level of toxicity, the effectiveness of the medication or the level of dose needed. Something that a doctor always has to supervise.
The genetic information provided by 24Genetics is valid only for research, information and educational uses. In no case is it valid for clinical or diagnostic use.
The reports we provide try to offer as much practical information as possible from the genetic data available in the test. In the case of many diseases, we report pathogenic mutations (or the absence of them) of only a part of the genes involved (which we can see in the test), which means that the disease may be present in areas that are not we are analyzing. If you have a family history, we recommend that you consult your doctor or geneticist to study the need to perform a test of this type.
24Genetics offers telephone consultation of genetic advice included in the price of the test. All the clients that request it will be able to have ten minutes of genetic advice offered by collegiate Biologists (available in Spanish or English).
Questions and answers:
Where is this test available?
In the whole planet. Place your order on the web and we will send it to any corner of the world.
How is this DNA test done?
It is very simple. We send you a kit with a cotton swab that you will have to rub in your mouth following some simple instructions. Depending on where you live and the service contracted, we will pick it up by a messenger or we will ask you to send it to us.
Do I have to go to your laboratories?
No, we send you the KIT home.
Should I make changes in the treatment of my health with the data of this test?
No, any change you want to make in your health should be analyzed by an expert geneticist and consulted with specialized doctors.
If it turns out that I have a greater genetic predisposition to a certain disease, will I have it safe?
No, all the genetic studies we do are based on statistics. You can have a genetic predisposition to a certain disease and never develop it and vice versa.
If there is no pathogenic genetic mutation in the test for a certain disease, does it mean that I am not a carrier?
No, this test analyzes only part of the genome, we see the pathologies only partially. There are genetic tests for clinical use that analyze all the genes involved that your doctor can prescribe in case it is advisable.
Does everything depend on my genes?
No, you are you and your experiences. Your life habits are a very important part. Having the information of your genes at hand is vital.
How do you protect my privacy?
We take our customer's information very seriously and treat it with the highest levels of security. From the moment your sample arrives, it becomes an anonymous code. It travels encrypted and no collaborator knows who it belongs to. Only at the time of sending the reports, the codes are crossed with the client to whom they belong.
Are you going to use my genetic information for research purposes?
Without your express consent, no.
Are all the genetic tests the same?
No, nor similar. There are some genetic tests based on less than 3.000 genetic markers while ours does on 700.000. We are the only ones in Europe that can adapt the algorithms to the ancestral roots of each one. We operate on Illumina equipment (the most prestigious) and our technological platforms are the most advanced in the market. We are able to offer more useful information, with better precision and more contrasted than the rest of the tests of this type available in the market.
What is this study based on?
It is based on genetic studies that are internationally consolidated and accepted by the scientific community. There are certain organisms and scientific databases where studies are published in which there is a broad level of consensus. Our genetic tests are carried out by applying these studies to the genotype of our clients.
From 24Genetics we recommend all our clients to accompany their genetic health test with a Genetic Counsel consultation.
Some studies on which our DNA health test is based.
- Ahmed S et al; Newly discovered breast cancer susceptibility loci on 3p24 and 17q23; Nat Genet; 2009 May; 41 (5): 585-90.
- Cox A et al; A common coding variant in CASP8 disassociated with breast cancer risk; Nat Genet; 2007 Sea; 39 (3): 352-8.
- Dickson C et al; Tyrosine kinase signaling in breast cancer: fibroblast growth factors and their receptors; Breast Cancer Res; 2000; 2 (3): 191-6.
- Easton DF et al; Genome-wide association study identifies novel breast cancer susceptibility loci; Nature; 2007 Jun28; 447 (7148): 1087-93.
- Hunter DJ et al; A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer; Nat Genet; 2007 Jul; 39 (7): 870-4.
- Chang YK et al; Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese; Immun Genes; 2009; 10 (5): 414-20.